Volume 33

Number 4 (2024)

Relation of Serum Ferritin Level with Severity of Neurological Disability among Patients with Acute Ischemic Stroke

DOI: https://doi.org/10.XXXXX/mmj.2024.v3304.04

Sakib AA1 , Miah MAH2 , Alam MK3 , Rashid MH4 , Mohsin M5 , Khan MM6 , Rahman MA7 , Mondal E8 , Noor RII9

Abstract

Stroke is one of the major causes of morbidity and mortality throughout the world.  Research is going on to find out the factors which are associated with the severity of acute ischemic stroke. One of the factors which has gained interest in the field of research in recent time is serum ferritin. Serum ferritin is an acute phase reactant. It is recently under research as a marker of severity and prognosis of acute ischemic stroke. The aim of this study was to assess the relation of serum ferritin level with the severity of acute ischemic stroke. This cross-sectional study was conducted in the Department of Medicine in Mymensingh Medical College Hospital, Bangladesh from June 2020 to March 2023. In this study, 323 patients with acute ischemic stroke were enrolled. The severity of neurological disability was evaluated in all participants using National Institute of Health stroke scale (NIHSS) within 48 hours of onset of stroke. Blood was taken for estimation of serum ferritin levels within 48 hours of admission. In this study, mean serum ferritin level was 208.3±161.1 ng/ml in patients with acute ischemic stroke. The study showed most of the participants with high serum ferritin level had severe stroke (n=57, 77.0%; p<0.001). A statistically significant correlation was found between NIHSS and serum ferritin levels in acute ischemic stroke patients (r=0.71). This study revealed that serum ferritin level is associated with severity of neurological disability among patients with acute ischemic stroke. Further studies are required to establish the role of serum ferritin as a prognostic marker of acute ischemic stroke.

Keywords: National institute of health stroke scale, Serum ferritin, Acute ischemic stroke


  1. Resident, Department of Internal Medicine

    Mymensingh Medical College, Mymensingh

  2. Professor and Head, Department of Medicine

    Mymensingh Medical College, Mymensingh

  3. Associate Professor, Department of Medicine

    Mymensingh Medical College, Mymensingh

  4. Associate Professor and Head, Department of Anesthesia and Intensive Care

    Mymensingh Medical College, Mymensingh

  5. Assistant Professor, Department of Medicine

    Mymensingh Medical College, Mymensingh

  6. Senior Consultant, Department of Medicine

    Mymensingh Medical College, Mymensingh

  7. Junior Consultant, Department of Medicine

    Mymensingh Medical College, Mymensingh

  8. Medical Officer, Department of Endocrinology

    Mymensingh Medical College, Mymensingh

  9. Resident, Internal Medicine

    Mymensingh Medical College, Mymensingh

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Volume 33, Number 4 (2024)
Page: 973-979