High-risk pregnancies may put women and their partners under a lot of emotional and physical strain. Several variables can enhance or decrease the dangers associated with a high-risk pregnancy, one of which is amniotic fluid, also known as liquor amnii. The aim of the study was to observe the risk factors of high-risk pregnancy cases among patients with and without meconium-stained liquor amnii. This cross-sectional comparative study was conducted at the Department of obstetrics and gynecology, Combined Military Hospital (CMH), Cantonment, Dhaka, Bangladesh. The study duration was 6 months, from February 2012 to July 2012. The study was conducted with a total of 86 women among those who were admitted to the high-risk antenatal ward of the study hospital. Total of 86 high-risk cases were taken for the study. Among them, 12(14.0%) were found with meconium-stained liquor (Group A) and 74(86.0%) cases were found without meconium-stained liquor (Group B). In Group A common risk factors were prolonged pregnancy (33.3%), then hypertensive disorder 25.0%. In Group B common risk factors were hypertensive disorder in 23.0% then diabetes in 18.9%. A cord around the neck was observed in 25.0% of cases in Group A in comparison to 8.1% in Group B. Participants with meconium-stained liquor amnii were shown to be at higher risk in all categories, according to the study. Severe high-risk pregnancy cases were more common in those with liquor amnii. Although the risk factor difference was greater in the group with meconium-stained liquid amnii, the difference was not statistically significant.