Does Vitamin D3 Supplementation Improve Cardiac Autonomic Nerve Function in Vitamin D3 Deficient Asthma COPD Overlap (ACO) Patients? A Randomized Clinical Trial

Yesmin SM1 , Sultana S2 , Ferdousi S3

Mymensingh Med J 2025 Apr; 34 (2): 530-537

PMID: 40160074

Abstract

Cardiac autonomic nerve dysfunction has been found associated with chronic obstructive pulmonary disease (COPD) patients as well as vitamin D3 deficient patients. Heart rate variability (HRV), one of the markers of cardiac autonomic nerve function which is reduced in Asthma COPD overlap (ACO) patients. Sympathovagal balanced was improved in healthy subjects after administration of vitamin D3. This randomized clinical trial aimed to observe the therapeutic effect of vitamin D3 supplementation on non linear measures of HRV in 60 male vitamin D3 deficient (<30 - 10 ng/ml) ACO patients. Patients were given orally either vitamin D3 capsule or placebo per week for 6 months and serum vitamin D3 level and non linear measures of HRV were assessed before and after intervention. HRV was measured by power lab 8/35, AD instruments and vitamin D3 was assessed by chemiluminescent micro-particle immunoassay (CMA) method by auto analyzer. For statistical analysis paired sample ‘t’ test and independent sample ‘t’ test were done. Before intervention vitamin D3 level and non linear parameters of HRV were similar in all patients but both these outcome measures significantly increased in vitamin D3 treated but not in placebo treated patients after 6 months. In conclusion, vitamin D3 supplementation is effective to improve HRV in vitamin D3 deficient ACO patients.

Keywords: HRV, Vitamin D3, Asthma COPD overlap (ACO)


  1. Assistent Professor

    Department of Physiology, Jalalabad Ragib Rabeya Medical College, Sylhet, Bangladesh


Volume 34, Number 2 (2025)
Page: 530-537