Volume 32 Number 1 (2023)

Paroxysmal Nocturnal Hemoglobinuria in Systemic Lupus Erythematosus: A Rare Manifestation

Hasan MN1 , Rahman BI2 , Rahaman MF3 , Biswas SK4 , Ahmed I5 , Rahman MA6

Mymensingh Med J 2023 Jan; 32 (1): 265-267

PMID: 36594332

Abstract

Paroxysmal nocturnal haemoglobinuria (PNH) is a rare disorder of hematopoietic stem cells. The occurrence of PNH in a patient with systemic lupus erythematosus (SLE) is even rarer. One such presentation was seen in a 19 years old woman who presented with fever, multiple joint pain, photosensitivity, oral ulcer, hair loss and was diagnosed as a case of SLE and was admitted in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh on 7th February 2019. Subsequently she developed progressive anaemia and passing of dark colored urine. Flow cytometry analysis showed PNH clone within red cells. We report this case so that clinicians are aware about this association between PNH and SLE. Informed written consent was obtained from the patient for the publication of this case report, the copy of which is available with the authors.

Keywords: Paroxysmal nocturnal hemoglobinuria, Systemic lupus erythematosus, Rare manifestation


  1. Associate Professor

    Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

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Volume 32, Number 1 (2023)
Page: 265-267